2,4-Difluorophenylboronic acid, identified by CAS 144025-03-6, is an aryl boronic acid used primarily as a fluorinated building block in organic synthesis. Its principal value is the boronic acid group, which can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or vinyl halides to form carbon–carbon bonds. The two fluorine substituents can also influence the electronic and metabolic properties of downstream molecules. At Maison Chemical, I support buyers by matching this compound’s specification, packaging, documentation, and supply plan to their actual research or production requirements.
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This guide is intended for medicinal chemists, process development teams, procurement specialists, contract research organizations, and chemical distributors evaluating 2,4-Difluorophenylboronic acid. It is also useful for buyers who need to compare catalog material with a more structured business-to-business supply arrangement. I focus on practical identification, application fit, specification review, and supplier evaluation rather than presenting unsupported performance claims.
The compound may be purchased for a small-scale reaction screen, a multistep synthesis, a pilot process, or an ongoing manufacturing program. Each use case creates different requirements for batch size, analytical documentation, packaging, and continuity of supply. A product suitable for exploratory chemistry should not automatically be treated as suitable for a regulated or scale-up process without additional qualification.
2,4-Difluorophenylboronic acid contains a phenyl ring bearing fluorine atoms at the 2- and 4-positions and a boronic acid functional group. The stated CAS number is 144025-03-6, while the commonly used molecular formula is C6H5BF2O2. Based on this formula, its calculated molecular weight is approximately 157.91 g/mol, which is an important value for reaction design, molar charging, and analytical calculations.
As an aromatic boronic acid, it should be handled as a chemical intermediate rather than as a finished active ingredient. The boronic acid functionality is chemically useful but may be sensitive to storage, moisture exposure, and reaction conditions depending on the formulation and intended process. I recommend that users rely on the supplier’s current certificate of analysis and safety documentation for batch-specific handling information.
Commercial material is commonly supplied as a solid, although the exact appearance, particle characteristics, and packaging format should be confirmed for the specific batch. Buyers should avoid assuming that appearance alone verifies quality because identity and purity require instrumental or documented analytical confirmation. For routine handling, users should follow the applicable safety data sheet, use appropriate personal protective equipment, and control exposure to dust or powder during weighing.
Storage requirements can vary with packaging, climate, and supplier recommendations. A buyer should confirm whether the material should be kept tightly closed, protected from moisture, or stored under a defined temperature range. If the compound will remain in inventory for an extended period, it is sensible to establish a retest or requalification policy rather than relying only on the original receipt date.
The most established use of aryl boronic acids is as coupling partners in carbon–carbon bond-forming reactions. In a typical Suzuki–Miyaura strategy, 2,4-difluorophenylboronic acid may be paired with a compatible aryl, heteroaryl, or vinyl halide under a catalyst, base, solvent, and temperature system selected for the substrate. The exact conversion and selectivity depend on the reaction design, so this compound should be evaluated through representative screening before scale-up.
The fluorinated aryl fragment can be introduced into a larger molecule in a single synthetic step when the coupling system is compatible. This can help route designers explore analogues with different electronic or lipophilic characteristics. However, the value of the building block depends on the complete reaction sequence, including substrate stability, catalyst choice, purification requirements, and the behavior of the resulting intermediate.
Fluorinated aromatic fragments are frequently considered during discovery and optimization programs because fluorine substitution can alter molecular properties. In this context, 2,4-difluorophenylboronic acid may serve as a research intermediate for preparing compound libraries or targeted analogues. It is not itself evidence of a pharmaceutical or agrochemical effect, and downstream activity must be established through the buyer’s own synthesis and testing program.
The compound may also be relevant to specialty organic synthesis where a difluorinated aromatic unit is needed in a larger molecular architecture. Potential areas include functional intermediates, research reagents, and materials-related building blocks. Since requirements differ substantially across these applications, I recommend confirming the intended reaction, scale, and analytical release criteria before selecting a supply grade.
For procurement purposes, the most important distinction is usually not a broad “research” or “industrial” label, but the actual specification and documentation attached to the batch. A buyer may request a standard commercial grade for exploratory work, a tighter internal specification for process development, or a customized packaging and testing arrangement for repeat production. Any enhanced specification should be agreed in writing rather than inferred from the product name.
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| Review Item | Why It Matters | What to Confirm |
|---|---|---|
| Identity | Confirms that the supplied intermediate is the requested compound. | CAS number, formula, molecular weight, and available analytical data. |
| Assay or purity | Influences stoichiometry, reaction reproducibility, and impurity load. | Specification basis, analytical method, and batch result. |
| Water and residual solvents | May affect sensitive coupling reactions and weighing calculations. | Test method, limits, and whether results are batch-specific. |
| Packaging | Protects the material during storage and transport. | Container type, net weight, labeling, and shipping configuration. |
| Documentation | Supports internal qualification and receiving procedures. | Certificate of analysis, SDS, and other agreed documents. |
First, I recommend defining whether the material is intended for route scouting, medicinal chemistry, process development, or commercial manufacturing support. This determines the acceptable batch size, purity target, documentation package, and continuity requirements. It also helps prevent overbuying a specification that the project does not need or under-specifying a material that will later enter a more demanding process.
Before approval, request the current product specification, certificate of analysis format, safety data sheet, packaging details, storage recommendations, and quotation validity. If analytical data are important to the project, clarify whether the reported results are representative or specific to the supplied batch. For international procurement, confirm export documents, labeling, customs information, and the destination country’s requirements at the quotation stage.
Price is only one part of sourcing risk. I suggest reviewing available inventory, normal production or replenishment timing, minimum order quantity, batch size flexibility, and the supplier’s ability to support repeat orders. Lead time is not a fixed property of CAS 144025-03-6; it can change with quantity, stock position, testing requirements, transport conditions, and destination.
For a new supplier or a new batch, a controlled laboratory evaluation is a practical decision point. Compare the material against the project’s reaction method and monitor relevant outcomes such as conversion, impurity profile, filtration behavior, or purification burden. This does not replace formal qualification, but it can reveal whether the selected specification is appropriate for the intended process.
The commercial price of 2,4-Difluorophenylboronic acid depends on quantity, specification, packaging, analytical requirements, and shipping destination. Small research quantities often carry higher unit costs because packaging and handling represent a larger share of the order. Larger orders may improve the unit economics, but they should be aligned with realistic consumption and storage capacity.
MOQ and lead time should be requested as quotation-specific terms rather than assumed from online listings. A buyer should also ask whether the quoted material is available from stock or scheduled for production, and whether the quoted lead time includes testing and export preparation. At Maison Chemical, I can review the required quantity, destination, documentation, and target delivery window before providing a supply proposal.
These mistakes can create avoidable delays even when the chemical identity is correct. A clear purchasing specification should identify the compound, required quantity, acceptable analytical criteria, documentation, packaging, delivery location, and schedule. When the application is still under development, I recommend keeping the specification practical and revisable rather than adding requirements that cannot be justified by the process.
Maison Chemical supports business-to-business sourcing of 2,4-Difluorophenylboronic acid CAS 144025-03-6 for research and development applications. I can help organize the information needed for a quotation, including target quantity, preferred packaging, destination, document requirements, and intended use. Where available and appropriate, the supply discussion can also address repeat-order planning and specification alignment.
Our role is to provide clear commercial communication without replacing the buyer’s internal quality, safety, or regulatory review. Product availability, price, MOQ, and lead time should be confirmed for each inquiry because they depend on the requested terms. Buyers who need this compound for a defined synthesis route should include the planned scale and any critical analytical requirements when contacting us.
2,4-Difluorophenylboronic acid CAS 144025-03-6 is a fluorinated aryl boronic acid building block primarily selected for carbon–carbon coupling and related organic synthesis. Its formula, calculated molecular weight, functional group, intended reaction, and batch documentation should all be considered together when evaluating suitability. The correct buying decision depends on more than unit price: specification fit, packaging, documentation, continuity, and delivery conditions are equally important.
For the next step, define your required quantity, application, purity or analytical criteria, packaging preference, destination, and desired delivery date. Send these details to Maison Chemical for a practical quotation and supply review. I will help you determine which information should be confirmed before purchase and whether the proposed material and service arrangement match your project stage.
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