If I were sourcing 3-Carboxyphenylboronic acid, CAS 25487-66-5, I would evaluate three areas first: confirmed identity, application-fit quality, and supply reliability. This aromatic boronic acid contains both a boronic acid group and a carboxylic acid group, making it a useful multifunctional intermediate for medicinal chemistry, process research, and organic synthesis. Its molecular formula is commonly reported as C7H7BO4, with a molecular weight of approximately 165.94 g/mol. For purchasing, I would not rely on a catalog name alone; I would request a current specification sheet, certificate of analysis, analytical data, packaging information, and lead-time confirmation.
Please visit our website for more information on this topic.
I have prepared this guide for procurement teams, pharmaceutical and fine-chemical manufacturers, medicinal chemistry groups, process development laboratories, and distributors evaluating 3-Carboxyphenylboronic acid. It is also relevant to buyers who are moving from milligram-scale research to gram- or kilogram-scale production. The right buying decision depends on the intended reaction, required purity, batch size, delivery region, and regulatory documentation needed by the end user. A specification that works for early screening may not be sufficient for a controlled manufacturing process.
3-Carboxyphenylboronic acid is an aromatic boronic acid derivative in which a carboxylic acid substituent and a boronic acid substituent are present on a benzene ring. The “3-carboxy” designation indicates the relative meta arrangement of these functional groups in the commonly used structure description. The compound is also described in some commercial and technical contexts as 3-boronobenzoic acid, although buyers should always verify that the synonym corresponds to CAS 25487-66-5. This verification is especially important when comparing suppliers or importing materials across different regions.
From a synthesis perspective, the molecule provides two chemically useful handles. The aryl boronic acid group is commonly considered for palladium-catalyzed Suzuki-type cross-coupling with suitable aryl or heteroaryl partners, while the carboxylic acid may participate in esterification, amidation, salt formation, or other functional-group transformations. Actual reaction performance depends on the reaction design, catalyst system, solvent, base, temperature, and substrate compatibility. I therefore recommend treating this compound as a versatile building block rather than assuming that every application will use both functional groups in the same step.
In pharmaceutical research, 3-Carboxyphenylboronic acid can be selected as an intermediate for preparing structurally diverse biaryl, heteroaryl, or further functionalized compounds. The boronic acid group may be used to introduce an aromatic fragment through cross-coupling, while the carboxylic acid can remain available for later conversion into an amide, ester, or other derivative. This combination can help chemists explore molecular polarity, linker design, and substitution patterns during lead optimization. However, the final suitability must be established through reaction-specific testing and analytical confirmation.
Process chemists may evaluate this material when they need a defined aromatic intermediate with more than one functional group. At larger scale, the focus usually expands beyond reaction conversion to include filtration behavior, impurity purge, solid-state handling, solvent compatibility, and reproducibility between batches. A supplier should be able to discuss available batch sizes and provide documentation that supports technical evaluation. I recommend confirming whether the quoted material is standard stock, made to order, or dependent on a scheduled production campaign.
Academic and commercial research groups may use the compound in library synthesis, route scouting, or preparation of reference intermediates. Small quantities can be appropriate for early experimentation, while larger quantities require stronger control of packaging, moisture exposure, labeling, and transport conditions. If the compound is being used in a multi-step route, I would also evaluate how the supplier handles repeat orders and batch-to-batch consistency. This can reduce the risk of changing reaction behavior during a project.
The first specification is identity. I would ask the supplier to confirm the product name, CAS number, molecular formula, molecular weight, lot number, and analytical methods used for release. A molecular weight of approximately 165.94 g/mol is a useful reference point for calculations, but it is not a substitute for identity testing. Where the material is used in a regulated or quality-sensitive workflow, I would request supporting spectra or chromatographic data rather than accepting an unqualified statement of purity.
| Specification Area | What I Would Confirm | Why It Matters |
|---|---|---|
| Identity | CAS 25487-66-5, formula, molecular weight, NMR or MS data | Reduces the risk of receiving a similar aromatic boronic acid |
| Purity | Assay method, HPLC or LC result, and impurity profile | Helps assess reaction reliability and downstream purification needs |
| Physical form | Powder or solid description, color range, and handling notes | Supports weighing, transfer, and process planning |
| Packaging | Container type, net weight, liner, labeling, and shipping configuration | Protects material integrity during storage and transport |
| Documentation | COA, SDS, product specification, and export documents where applicable | Supports internal approval and international purchasing |
Purity requirements should be connected to the application rather than selected automatically. Many research buyers may begin by requesting a specification such as 98% or higher, but the appropriate limit depends on the synthetic route, known impurities, and purification strategy. I would ask whether the reported assay is area percentage, corrected assay, or another method, because these values may not be directly comparable. Water content, residual solvents, inorganic residues, and boron-containing impurities may also deserve attention when they can affect a sensitive reaction.
I begin by documenting the reaction type, target quantity, required delivery date, and expected repeat-order frequency. A material for route screening may have different documentation needs from a material intended for process validation or commercial intermediate production. I also identify whether the buyer needs a standard commercial grade or a project-specific specification. This information allows the supplier to provide a more realistic quotation and feasibility response.
With competitive price and timely delivery, Maison Chemical sincerely hope to be your supplier and partner.
I compare suppliers using the same checklist rather than comparing price alone. The review should include the latest COA, test methods, typical impurity information, packaging, storage guidance, and a clear statement of whether the data are lot-specific. If a supplier cannot explain how identity and purity are determined, I would treat the offer as incomplete. For repeat supply, I would also ask how specification changes are communicated.
MOQ and lead time vary according to stock status, quantity, production scheduling, packaging, and destination. I would request a written distinction between in-stock delivery and manufacturing lead time, because these are not equivalent. Buyers should also confirm whether the quotation includes export packaging, documentation, freight assumptions, and any special handling requirements. A low unit price may not represent the lowest total procurement cost if the material requires urgent shipping or repeated small orders.
Before approving a larger purchase, I recommend asking whether the evaluation sample and production batch will be made to the same specification. Where practical, the buyer should compare key analytical results between sample and bulk material. This is particularly useful when the compound will enter a multi-step synthesis with narrow impurity tolerance. It also creates a clearer technical basis for future repeat orders.
One common mistake is selecting a product solely by the name “carboxyphenylboronic acid” without checking the positional isomer and CAS number. Another is assuming that a stated purity value fully describes the impurity profile or moisture condition. I also advise buyers not to postpone packaging and transport discussions until after the purchase order, because these details can affect stability, customs clearance, and receiving procedures.
A further mistake is requesting an exact delivery date without providing quantity, destination, packaging preference, or documentation requirements. Suppliers can usually respond more accurately when the inquiry contains these details. Finally, buyers should avoid assuming that a research-grade specification automatically meets internal manufacturing, regulatory, or customer requirements. Those requirements should be reviewed before order confirmation.
At Maison Chemical, I approach 3-Carboxyphenylboronic acid supply as a technical B2B project rather than a simple product transaction. I can help buyers review the requested specification, clarify quantity and packaging needs, and coordinate documentation for internal evaluation. Depending on the project, the discussion may cover sample availability, production planning, repeat-order expectations, and export requirements. All commercial and technical details should be confirmed for the specific batch and destination before purchase.
For an efficient inquiry, I recommend sending the CAS number, required quantity, target purity, intended application, delivery country, desired delivery window, and documentation list. If a buyer has an existing specification or analytical method, sharing it can help Maison Chemical assess alignment more precisely. We can then provide a quotation or feasibility response based on the actual requirement rather than a generic catalog assumption.
3-Carboxyphenylboronic acid CAS 25487-66-5 is a useful bifunctional aromatic intermediate for cross-coupling research, pharmaceutical intermediate development, and broader fine-chemical synthesis. The best purchasing decision depends on verified identity, application-appropriate purity, analytical transparency, packaging, and dependable supply planning. I recommend comparing suppliers through a documented checklist and confirming sample-to-bulk continuity before committing to a larger quantity.
As a next step, prepare your required quantity, specification, destination, delivery schedule, and documentation needs, then contact Maison Chemical for a product and supply discussion. By evaluating the chemistry and the procurement conditions together, I can help you move from initial screening toward a more predictable B2B sourcing decision.
If you want to learn more, please visit our website 3-Carboxyphenylboronic acid CAS 25487-66-5.