3,5-Difluorophenylboronic acid, identified by CAS 156545-07-2, is an aromatic boronic acid used mainly as a building block in organic synthesis. Its most established role is as a coupling partner in palladium-catalyzed Suzuki–Miyaura reactions, where it can help introduce a 3,5-difluorophenyl group into a target molecule. The compound is commonly described by the molecular formula C6H5BF2O2 and a calculated molecular weight of approximately 157.93 g/mol. At Maison Chemical, we support buyers who need this intermediate for pharmaceutical research, agrochemical development, medicinal chemistry, and other synthesis programs.
3,5-Difluorophenylboronic acid is an organoboron compound containing a phenyl ring substituted with fluorine atoms at the 3 and 5 positions and a boronic acid group attached to the ring. The boronic acid functionality is chemically useful because it can participate in carbon–carbon bond-forming reactions under suitable conditions. The two fluorine substituents can also influence the electronic and lipophilic characteristics of the resulting aromatic structure.
As with many specialty organic intermediates, the practical value of this material depends on more than its name or CAS number. Buyers should confirm identity, assay, water content, residual solvents, appearance, packaging, and analytical documentation for each lot. I recommend treating the stated molecular formula and molecular weight as identification references, while using the supplier’s current specification and certificate of analysis for release decisions.
The primary synthetic function of 3,5-Difluorophenylboronic acid is to provide a difluorinated aryl fragment during cross-coupling. In a typical Suzuki–Miyaura transformation, the boronic acid reacts with an appropriate aryl or heteroaryl halide in the presence of a catalyst, base, solvent, and controlled reaction conditions. The exact yield and selectivity depend on the reaction partners, catalyst system, base, temperature, concentration, and work-up procedure, so they should be established experimentally rather than assumed.
Fluorine substitution is frequently used in medicinal and discovery chemistry to adjust molecular properties such as metabolic behavior, polarity, and electronic distribution. However, the effect of a 3,5-difluorophenyl group is specific to the complete target structure and cannot be generalized to every compound. For this reason, the material is best viewed as a reliable synthetic option rather than as a guaranteed performance-enhancing additive.
Pharmaceutical and medicinal chemistry teams may use this intermediate when preparing small molecules that contain a difluorinated biaryl or heteroaryl–aryl motif. It can be valuable during hit expansion, analog preparation, structure–activity relationship studies, and route scouting. In these settings, small package quantities and dependable lot-to-lot documentation may be more important than immediate bulk capacity.
Agrochemical research can also use fluorinated aromatic building blocks during the development of active-ingredient candidates and related intermediates. The compound may be incorporated into a larger synthesis sequence rather than used as a final active substance. Any application involving regulatory submission, process scale-up, or commercial production should include a documented assessment of impurity profile, trace metals, residual solvents, and process compatibility.
Academic and contract research laboratories may select 3,5-Difluorophenylboronic acid for method development or library synthesis. In these cases, practical considerations include whether the supplier can provide a small research quantity, clear shipping information, repeat supply, and technical responses regarding storage or analytical results. The most suitable grade is determined by the project’s reaction requirements and quality system.
Buyers may encounter several related boronic acid materials, including unsubstituted phenylboronic acid, monofluorinated phenylboronic acids, other difluorophenylboronic acid isomers, and protected boronate esters. These materials are not interchangeable solely because they contain a boronic acid or boronate group. Substitution pattern, steric environment, electronic properties, solubility, and reactivity can all affect the outcome of a coupling reaction.
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3,5-Difluorophenylboronic acid should therefore be selected when the target synthesis specifically requires the 3,5-difluorophenyl fragment or when the route has been designed around this substrate. A boronate ester may be considered when improved handling or storage characteristics are required, but conversion, purification, and compatibility must be evaluated for the individual process. I advise buyers to confirm the exact structure and CAS number before placing a purchase order.
| Specification area | Why it matters | What to confirm |
|---|---|---|
| Identity | Confirms that the material matches the intended intermediate | CAS 156545-07-2, structure, molecular formula, and analytical identification |
| Assay or purity | Influences stoichiometry and impurity burden | Specification basis, test method, and lot-specific result |
| Water and residual solvents | May affect reaction performance and weighing calculations | Test method, acceptance limits, and current certificate of analysis |
| Physical form | Supports handling, sampling, and process planning | Powder or solid description, color range, and packaging format |
| Packaging and storage | Helps protect material quality during transport and use | Container type, net weight, storage guidance, and retest information if applicable |
The reference molecular weight is approximately 157.93 g/mol, which can be used for preliminary stoichiometric calculations. A buyer planning a 10 mmol reaction would theoretically require about 1.58 g before accounting for purity, excess, process loss, or the selected reaction ratio. This calculation is only a planning reference; the actual weighed quantity should be based on the lot-specific assay and the validated procedure.
A competitive quotation is useful, but it should not be the only selection criterion. I recommend asking for a current product specification, a representative or lot-specific certificate of analysis when available, available analytical data, packaging details, and expected lead time. Buyers should also clarify whether the quoted material is from regular stock, scheduled production, or a custom manufacturing arrangement.
The right supplier depends on the project stage. A discovery program may need a few grams or tens of grams, while process development may require larger quantities with tighter change-control expectations. Maison Chemical can discuss research, development, and production-oriented requirements so that the proposed package size and supply plan match the customer’s actual use case.
International chemical purchasing involves more than product availability. Before ordering, confirm the shipping destination, packaging configuration, customs information, labeling requirements, and any transport restrictions that may apply to the shipment. Storage conditions should follow the supplier’s current product documentation, and the customer should assess compatibility with its own warehouse and laboratory procedures.
At Maison Chemical, we supply 3,5-Difluorophenylboronic acid CAS 156545-07-2 for customers evaluating fluorinated organic building blocks. Our support focuses on clear product identification, specification communication, quantity planning, packaging coordination, and export-oriented order handling. We avoid treating one specification as suitable for every application, because the required quality profile can differ between screening, route development, and manufacturing.
When reviewing an inquiry, I recommend that customers provide the required quantity, intended application stage, destination country, preferred delivery schedule, and any quality or documentation requirements. This information helps us prepare a more relevant quotation and identify whether standard supply or a tailored discussion is appropriate. Where additional analytical or technical information is needed, we can clarify what is available for the requested lot or product grade.
3,5-Difluorophenylboronic acid CAS 156545-07-2 is the appropriate choice when a synthesis requires a defined 3,5-difluorophenyl building block, particularly for planned cross-coupling chemistry. Its usefulness comes from the combination of a reactive boronic acid group and a fluorinated aromatic structure, but actual reaction performance must be confirmed in the customer’s own system. The next practical step is to compare the required quantity, specification, analytical documentation, and delivery timing with the project’s needs.
If you are sourcing this compound, send Maison Chemical your target quantity, destination, required grade, and expected delivery window. We can then discuss product documentation, packaging, supply availability, and a quotation for your application. This approach helps convert a basic CAS-number search into a more reliable B2B purchasing decision.
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